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Newly widowed Helen Blacke inherits the Blacke Foundation, a scientific research institute located in the Highcliffe Manor on an island off the Massachusetts coast and populated by mad scientists who want to get rid of her.

Shelley Fabares
Helen Straight Blacke

Stephen McHattie
Rev. Ian Glenville
Eugenie Ross-Leming
Dr. Frances Kisgadden

Gerald Gordon
Felix Morger

Audrey Landers
Wendy Sparkles

Jenny O'Hara
Rebecca
Chris Marlowe
Bram Shelley

David Byrd
Dr. Lester

Luis Ávalos
Dr. Sanchez

Ernie Hudson
Smythe

Harold Sakata
Cheng